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Publications

2018


Kelly Thompson; Sarah Moore; Shirley Tang; Matthew Wiet; Devina Purmessur, 2018, "The chondrodystrophic dog: A clinically relevant intermediate‐sized animal model for the study of intervertebral disc‐associated spinal pain.", JOR Spine. Volume 1, Issue 1. 

2017

Wiet MG; Piscioneri A; Khan SN; Ballinger MN; Hoyland JA; Purmessur D., 2017, "Mast Cell-Intervertebral disc cell interactions regulate inflammation, catabolism and angiogenesis in Discogenic Back Pain." Scientific Reports 7, no.12492.


Palacio-Mancheno, P. E.; Evashwick-Rogler, T. W.; Laudier, D. M.; Purmessur, D; and Iatridis, J. C. (2017), "Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression. "J. Orthop. Res.. doi:10.1002/jor.23715

2016

William S. Marras;  Benjamin A. Walter; Devina Purmessur;  Prasath Mageswaran;  Matthew G. Wiet; 2016, "The Contribution of Biomechanical-Biological Interactions of the Spine to Low Back Pain." Human Factors Vol 58, no. 7, 965-975


Alon Lai; Andrew Moon; Devina Purmessur; Branko Skovrlj; Damien M. Laudier; Beth A. Winkelstein; Samuel K. Cho; Andrew C. Hecht; James C. Iatridis; 2016,  "Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo." The Spine Journal, Volume 16, no. 3, 2016, 420-431.

2015

Alon, Lai; Andrew, Moon; Devina, Purmessur; Branko,Skovrlj; Damien M.Laudier; Beth A.Winkelstein; Samuel K.Cho; Andrew C.Hect; James C.Iatridis, 2015, "Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo.", The Spine Journal 16, no.3, 420-431.


Walter, Benjamin A.; Purmessur, Devina; Likhitpanichkul, Morakot; Weinberg, Alan; Cho, Samuel K.; Qureshi, Sheeraz A.; Hecht, Andrew C; Iatridis, James C. PhD, 2015, "Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells.", The Spine Journal  40, no.13, 955-963.


Cornejo,M,C; Cho,S,K; Giannarelli,C; Iatridis,J,C; Purmessur,D, 2015, "Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines."OSTEOARTHRITIS AND CARTILAGE 23, no. 3, 487 - 496.



Purmessur,Devina; Cornejo,Marisa,C; Cho,Samuel,K; Roughley,Peter,J; Linhardt,Robert,J; Hecht,Andrew,C; Iatridis,James,C,2015, "Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability." SPINE JOURNAL 15, no. 5, 1060 - 1069.



Lai,Alon; Moon,Andrew; Purmessur,Devina; Skovrlj,Branko; Winkelstein,Beth,A; Cho,Samuel,K; Hecht,Andrew,C; Iatridis,James,C, 2015, "Assessment of Functional and Behavioral Changes Sensitive to Painful Disc Degeneration."JOURNAL OF ORTHOPAEDIC RESEARCH 33, no. 5, 755 - 764.


2014

Lu,Young; Guzman,Javier,Z; Purmessur,Devina; Iatridis,James,C; Hecht,Andrew,C; Qureshi,Sheeraz,A; Cho,Samuel,K, 2014, "Nonoperative Management of Discogenic Back Pain A Systematic Review." SPINE 39, no. 16, 1314 - 1324.



Illien-Jünger,Svenja; Lu,Young; Purmessur,Devina; Mayer,Jillian,E; Walter,Benjamin,A; Roughley,Peter,J; Qureshi,Sheeraz,A; Hecht,Andrew,C; Iatridis,James,C, 2014, "Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model.." spine journal 14, no. 11, 2724 -2732.



Guterl,Clare,C; Torre,Olivia,M; Purmessur,Devina; Dave,Khyati; Likhitpanichkul,Morakot; Hecht,Andrew,C; Nicoll,Steven,B; Iatridis,James,C, 2014, "Characterization of Mechanics and Cytocompatibility of Fibrin-Genipin Annulus Fibrosus Sealant with the Addition of Cell Adhesion Molecules." TISSUE ENGINEERING PART A 20, no. 17-18, 2536 - 2545.



Illien-Juenger,Svenja; Lu,Young; Purmessur,Devina; Mayer,Jillian,E; Walter,Benjamin,A; Roughley,Peter,J; Qureshi,Sheeraz,A; Hecht,Andrew,C; Iatridis,James,C, 2014, "Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model." SPINE JOURNAL 14, no. 11,2724 - 2732.


2013

Purmessur,Devina; Guterl,Clare,C; Cho,Samuel,K; Cornejo,Marisa,C; Lam,Ying,W; Ballif,Bryan,A; Laudier,Damien,M; Iatridis,James,C, 2013, "Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development." ARTHRITIS RESEARCH & THERAPY 15, no. 5, R122-



Abbott,Rosalyn,D; Purmessur,Devina; Monsey,Robert,D; Brigstock,David,R; Laudier,Damien,M; Iatridis,James,C, 2013, "Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGF beta 3." JOURNAL OF SPINAL DISORDERS & TECHNIQUES 26, no. 3, E86 - E94.



Purmessur,D; Walter,B,A; Roughley,P,J; Laudier,D,M; Hecht,A,C; Iatridis,James, 2013, "A role for TNF alpha in intervertebral disc degeneration: A non-recoverable catabolic shift." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS433, no. 1, 151 - 156.



Purmessur,D; Cornejo,M,C; Cho,S,K; Hecht,A,C; Iatridis,J,C, 2013, "Notochordal cell-derived therapeutic strategies for discogenic back pain.." Global spine journal 3, no. 3, 201 - 218.


2012

Richardson,Stephen,M; Purmessur,Devina; Baird,Pauline; Probyn,Ben; Freemont,Anthony,J; Hoyland,Judith,A, 2012, "Degenerate Human Nucleus Pulposus Cells Promote Neurite Outgrowth in Neural Cells." PLOS ONE 7, no. 10, e47735 -



Abbott,Rosalyn,Delia; Purmessur,Devina; Monsey,Robert,Daniel; Iatridis,James,Christopher, 2012, "Regenerative potential of TGF beta 3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells." JOURNAL OF ORTHOPAEDIC RESEARCH 30, no. 3, 482 - 488.


2011

Purmessur,Devina; Schek,Rachel,M; Abbott,Rosalyn,D; Ballif,Bryan,A; Godburn,Karolyn,E; Iatridis,James,C, 2011, "Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells." ARTHRITIS RESEARCH & THERAPY 13, no. 3, R81 -



Walter,B,A; Korecki,C,L; Purmessur,D; Roughley,P,J; Michalek,A,J; Iatridis,J,C, 2011, "Complex loading affects intervertebral disc mechanics and biology." OSTEOARTHRITIS AND CARTILAGE 19, no. 8, 1011 - 1018.


2009

Iatridis,James,C; Michalek,A,J; Purmessur,D; Korecki,C,L, 2009, "Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis." CELLULAR AND MOLECULAR BIOENGINEERING 2, no. 3, 437 - 447.


2008

Purmessur,Devina; Freemont,Anthony,J; Hoyland,Judith,A, 2008, "Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc." ARTHRITIS RESEARCH & THERAPY 10, no. 4, R99 -


2006

Purmessur,D; Hoyland,J,A; Freemont,A,J, 2006, "Disc cell/neural cell interactions in the intervertebral disc (IVD) and their role in degeneration of the IVD." JOURNAL OF PATHOLOGY 210, 25 - 25.



Parker,S,M; Purmessur,D; Millward-Sadler,S,J; LeMaitre,C,L; Freemont,A,J; Hoyland,J,A, 2006, "The identification of large conductance potassium (MaxiK) channels in human intervertebral disc (IVD) cells." JOURNAL OF PATHOLOGY 210, 24 - 24.